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Detection of Keto Synthase (KS) Gene Domain in Sponges and Bacterial Sponges

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Sponges are sources of various useful natural products. The natural compounds derived from sponges are mostly complex polyketide. The polyketide synthase genes (PKS) is responsible for the biosynthesis of complex polyketides. During this research, we detected ketosynthasc (KS) gene domain from 10 species of marine sponges, collected from Mediterranean Sea (Aplysina aerophoba, Petrocia ficiformis, Axinella dam icornis, Axinella veronicas, Crambe crambe) and North Sea (‘Halichondria panicea, Haliclona xena, Ilaliclona oculata, Suberites inassa, Ephydatia fluviatilis,). We also detected KS gene domain from 12 bacterial sponge isolated from H. panacea. We used a PCR-based approach to detect the ketosynthase (KS) gene domain of Polykctosynthase (PKS) genes. Our result showed that the sponges and the bacterial sponges are mostly KS- positive (700 bp). The presence of the PKS gene indicates the ability of the sponges to produce bioactive compound and potential natural product. The presence of the KS domain in both of the sponges and the bacterial sponges might also indicate that the bacterial sponges involved in the biosintesis of secondary metabolite of the sponges.

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Informasi Detail

Judul Seri

Annales bogorienses

No. Panggil

660.6 Ann

Penerbit

: Prentice Limited., 2013

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

0517-8452

Klasifikasi

660.6

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Vol. 17, No. 2, Tahun

Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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